Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Abstract Allopregnanolone, a 3α, 5α‐progesterone metabolite, acts as a potent allosteric
modulator of the γ‐aminobutyric acid type A receptor. In the present review, the synthesis of …

Progesterone is well known as a female reproductive hormone and in particular for its role in
uterine receptivity, implantation, and the maintenance of pregnancy. However …

All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous
physiological processes. The concentration of retinoic acid in the cells is tightly regulated …

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid
metabolism. Long known members of the protein family seemed to be well characterised …

Background: 17-Hydroxyprogesterone (17-OHP) can be converted to dihydrotestosterone
(DHT) via an alternative “backdoor” route that bypasses the conventional intermediates …

Premenstrual dysphoric disorder (PMDD) afflicts 3%‐5% of women of childbearing age, and
is characterised by recurrent negative mood symptoms (eg, irritability, depression, anxiety …

Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

Adrenal C 19 steroids serve as precursors to active androgens in the prostate.
Androstenedione (A4), 11β-hydroxyandrostenedione (11OHA4) and 11β …