Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

MicroRNA signatures in human cancers

GA Calin, CM Croce - Nature reviews cancer, 2006 - nature.com
MicroRNA (miRNA) alterations are involved in the initiation and progression of human
cancer. The causes of the widespread differential expression of miRNA genes in malignant …

[HTML][HTML] miRWalk–database: prediction of possible miRNA binding sites by “walking” the genes of three genomes

H Dweep, C Sticht, P Pandey, N Gretz - Journal of biomedical informatics, 2011 - Elsevier
MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the
mRNA 3′-UTR region to regulate the gene expression by transcriptional repression or …

MicroRNAs: small RNAs with a big role in gene regulation

L He, GJ Hannon - Nature reviews genetics, 2004 - nature.com
MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a
sequence-specific manner. The two founding members of the microRNA family were …

New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles

MA Zaimy, N Saffarzadeh, A Mohammadi… - Cancer Gene …, 2017 - nature.com
Cancer is one of the leading cause of death in the world with the prevalence of> 10 million
mortalities annually. Current cancer treatments include surgical intervention, radiation, and …

[HTML][HTML] The role of microRNAs in human diseases

AM Ardekani, MM Naeini - Avicenna journal of medical …, 2010 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

GA Calin, C Sevignani, CD Dumitru… - Proceedings of the …, 2004 - National Acad Sciences
A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs).
Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently …

miR-15 and miR-16 induce apoptosis by targeting BCL2

A Cimmino, GA Calin, M Fabbri… - Proceedings of the …, 2005 - National Acad Sciences
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is
characterized by predominantly nondividing malignant B cells overexpressing the …

[HTML][HTML] RAS is regulated by the let-7 microRNA family

SM Johnson, H Grosshans, J Shingara, M Byrom… - Cell, 2005 - cell.com
MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including
humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal …

miR2Disease: a manually curated database for microRNA deregulation in human disease

Q Jiang, Y Wang, Y Hao, L Juan, M Teng… - Nucleic acids …, 2009 - academic.oup.com
Abstract 'miR2Disease', a manually curated database, aims at providing a comprehensive
resource of microRNA deregulation in various human diseases. The current version of …