The human solute carrier (SLC) transporters are important targets for drug development.
Structure-based drug discovery for SLC transporters requires the description of their …

The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …

The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the
intestinal epithelium and lumen,,,–. However, whether 5-HT plays a functional role in …

Membrane transporters play diverse roles in the pharmacokinetics and pharmacodynamics
of small‐molecule drugs. Understanding the mechanisms of drug‐transporter interactions at …

Abstract FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and
shape of the endoplasmic reticulum. The structure of its reticulon-homology domain (RHD) …

Degradation of the endoplasmic reticulum (ER) via selective autophagy (ER‐phagy) is vital
for cellular homeostasis. We identify FAM134A/RETREG2 and FAM134C/RETREG3 as ER …

Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-
dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant …

The hair cell mechanotransduction (MET) channel complex is essential for hearing, yet it's
molecular identity and structure remain elusive. The transmembrane channel–like 1 (TMC1) …

Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft,
a key step in neurotransmission, which is targeted in the treatment of neurological disorders …

Glycosylation is a fundamental cellular process that, in eukaryotes, occurs in the lumen of
both the Golgi apparatus and the endoplasmic reticulum. Nucleotide sugar transporters …