Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

WT O'Brien, L Pham, GF Symons, M Monif… - Journal of …, 2020 - Springer
There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …

The effect of combined treatment of psilocybin and eugenol on lipopolysaccharide-induced brain inflammation in mice

T Zanikov, M Gerasymchuk, E Ghasemi Gojani… - Molecules, 2023 - mdpi.com
Inflammation is an organism's biological defense mechanism. Acute and chronic
inflammation of the body triggers the production of pro-and anti-inflammatory pathways that …

Immune modulation after traumatic brain injury

M Bouras, K Asehnoune, A Roquilly - Frontiers in Medicine, 2022 - frontiersin.org
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue,
followed by a systematization of the inflammatory response. The subsequent response …

Microglia dynamics in adolescent traumatic brain injury

E Eyolfson, A Khan, R Mychasiuk… - Journal of …, 2020 - Springer
Repetitive, mild traumatic brain injuries (RmTBIs) are increasingly common in adolescents
and encompass one of the largest neurological health concerns in the world. Adolescence is …

[HTML][HTML] Exercise and neuroinflammation in health and disease

DY Seo, JW Heo, JR Ko, HB Kwak - International neurourology …, 2019 - ncbi.nlm.nih.gov
Neuroinflammation is a central pathological feature of several acute and chronic brain
diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral …

Clinical utility of SPECT neuroimaging in the diagnosis and treatment of traumatic brain injury: a systematic review

CA Raji, R Tarzwell, D Pavel, H Schneider, M Uszler… - PloS one, 2014 - journals.plos.org
Purpose This systematic review evaluated the clinical utility of single photon emission
computed tomography (SPECT) in traumatic brain injury (TBI). Methods After defining a …

The immune system's role in the consequences of mild traumatic brain injury (concussion)

LN Verboon, HC Patel, AD Greenhalgh - Frontiers in immunology, 2021 - frontiersin.org
Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common
form of TBI and affects millions of people each year. A history of mild TBI increases the risk of …

Concussion: beyond the cascade

KD Neumann, DK Broshek, BT Newman, TJ Druzgal… - Cells, 2023 - mdpi.com
Sport concussion affects millions of athletes each year at all levels of sport. Increasing
evidence demonstrates clinical and physiological recovery are becoming more divergent …

Treatment with the vascular endothelial growth factor-A antibody, bevacizumab, has sex-specific effects in a rat model of mild traumatic brain injury

M Sun, TL Baker, CT Wilson, RD Brady… - Journal of Cerebral …, 2024 - journals.sagepub.com
Mild traumatic brain injury (mTBI) involves damage to the cerebrovascular system. Vascular
endothelial growth factor-A (VEGF-A) is an important modulator of vascular health and VEGF …