Chemo‐proteomics in antimalarial target identification and engagement
Humans have lived in tenuous battle with malaria over millennia. Today, while much of the
world is free of the disease, areas of South America, Asia, and Africa still wage this war with …
world is free of the disease, areas of South America, Asia, and Africa still wage this war with …
Phthalimide analogs for antimalarial drug discovery
Malaria remains one of the world's most life-threatening diseases and, thus, it is a major
public health concern all around the world. The disease can become devastating if not …
public health concern all around the world. The disease can become devastating if not …
Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA‐Infected Mice: A Novel Approach for Malaria Prophylaxis
Malaria is a prevalent vector‐borne infectious disease in tropical regions, particularly in the
absence of effective vaccines and because of the emergence resistance of Plasmodium to …
absence of effective vaccines and because of the emergence resistance of Plasmodium to …
Oral Administration of Piperine as Curative and Prophylaxis Reduces Parasitaemia in Plasmodium berghei ANKA‐Infected Mice
Malaria remains a public health problem and a leading cause of death worldwide.
Consequently, the discovery of novel agents, including substances from medicinal plants, is …
Consequently, the discovery of novel agents, including substances from medicinal plants, is …
Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum
A series of morpholine analogs functionalized with hydroxyethylamine (HEA)
pharmacophore was synthesized and assayed for the initial screening against Plasmodium …
pharmacophore was synthesized and assayed for the initial screening against Plasmodium …
The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel
Malaria elimination urgently needs novel antimalarial therapies that transcend resistance,
toxicity, and high costs. Our multicentric international collaborative team focuses on …
toxicity, and high costs. Our multicentric international collaborative team focuses on …
Comprehensive network analysis reveals the targets and potential multitarget drugs of type 2 diabetes mellitus
W Zhou, Q Liu, W Wang, XJ Yuan… - … Medicine and Cellular …, 2022 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a metabolic disease with increasing prevalence and
mortality year by year. The purpose of this study was to explore new therapeutic targets and …
mortality year by year. The purpose of this study was to explore new therapeutic targets and …
Phenotypic screening reveals a highly selective phthalimide-based compound with antileishmanial activity
F Zahedifard, M Bansal, N Sharma… - PLOS Neglected …, 2024 - journals.plos.org
Pharmacophores such as hydroxyethylamine (HEA) and phthalimide (PHT) have been
identified as potential synthons for the development of compounds against various parasitic …
identified as potential synthons for the development of compounds against various parasitic …
In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues
Abstract Drug-resistant Plasmodium falciparum (Pf) infections are a major burden on the
population and the healthcare system. The establishment of Pf resistance to most existing …
population and the healthcare system. The establishment of Pf resistance to most existing …
[HTML][HTML] Transmission-Blocking Strategies for Malaria Eradication: Recent Advances in Small-Molecule Drug Development
F Appetecchia, E Fabbrizi, F Fiorentino, S Consalvi… - Pharmaceuticals, 2024 - mdpi.com
Malaria drug research and development efforts have resurged in the last decade following
the decelerating rate of mortality and malaria cases in endemic regions. The inefficiency of …
the decelerating rate of mortality and malaria cases in endemic regions. The inefficiency of …