SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

PJ Halfmann, S Iida, K Iwatsuki-Horimoto, T Maemura… - Nature, 2022 - nature.com
The recent emergence of B. 1.1. 529, the Omicron variant,, has raised concerns of escape
from protection by vaccines and therapeutic antibodies. A key test for potential …

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - Cell, 2022 - cell.com
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …

Neuroinflammation and COVID-19

A Vanderheiden, RS Klein - Current opinion in neurobiology, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of
respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms …

[HTML][HTML] The SARS-CoV-2 B. 1.1. 529 Omicron virus causes attenuated infection and disease in mice and hamsters

M Diamond, P Halfmann, T Maemura… - Research …, 2021 - ncbi.nlm.nih.gov
Despite the development and deployment of antibody and vaccine countermeasures, rapidly-
spreading SARS-CoV-2 variants with mutations at key antigenic sites in the spike protein …

Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation

OO Oyesola, KL Hilligan, S Namasivayam… - Science …, 2023 - science.org
Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show
that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus …

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

EG Viox, TN Hoang, AA Upadhyay, R Nchioua… - Science …, 2023 - science.org
Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …

[HTML][HTML] Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

M Gagne, KS Corbett, BJ Flynn, KE Foulds, DA Wagner… - Cell, 2022 - cell.com
Summary mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time;
however, there are limited data on the impact of durability of immune responses on …

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

M Ranjbar, A Rahimi, Z Baghernejadan… - International …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …