Role of the metastasis‐promoting protein osteopontin in the tumour microenvironment

PH Anborgh, JC Mutrie, AB Tuck… - Journal of cellular and …, 2010 - Wiley Online Library
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to
multiple post‐translational modifications, including phosphorylation, glycosylation …

Pre-and post-translational regulation of osteopontin in cancer

PH Anborgh, JC Mutrie, AB Tuck… - Journal of cell …, 2011 - Springer
Osteopontin (OPN) is a matricellular protein that binds to a number of cell surface receptors
including integrins and CD44. It is expressed in many tissues and secreted into body fluids …

Hybrids of a genetically engineered antibody and a carbon nanotube transistor for detection of prostate cancer biomarkers

MB Lerner, J D'Souza, T Pazina, J Dailey… - Acs Nano, 2012 - ACS Publications
We developed a novel detection method for osteopontin (OPN), a new biomarker for
prostate cancer, by attaching a genetically engineered single-chain variable fragment (scFv) …

Electrochemical aptasensor for human osteopontin detection using a DNA aptamer selected by SELEX

SG Meirinho, LG Dias, AM Peres, LR Rodrigues - Analytica chimica acta, 2017 - Elsevier
A DNA aptamer with affinity and specificity for human osteopontin (OPN), a potential breast
cancer biomarker, was selected using the SELEX process, considering its homology rate …

Single-walled carbon nanotube based transparent immunosensor for detection of a prostate cancer biomarker osteopontin

A Sharma, S Hong, R Singh, J Jang - Analytica chimica acta, 2015 - Elsevier
Osteopontin (OPN) is involved in almost all steps of cancer development, and it is being
investigated as a potential biomarker for a diagnosis and prognosis of prostate cancer. Here …

[HTML][HTML] Structure, function and nutritional potential of milk osteopontin

B Christensen, ES Sørensen - International Dairy Journal, 2016 - Elsevier
Osteopontin (OPN) is a multifunctional protein present in most tissues and body fluids, with
the highest concentrations found in milk. Processes for isolation of OPN from bovine milk for …

Plasma osteopontin as a biomarker of prostate cancer aggression: relationship to risk category and treatment response

JW Thoms, A Dal Pra, PH Anborgh… - British journal of …, 2012 - nature.com
Background: High plasma osteopontin (OPN) has been linked to tumour hypoxia,
metastasis, and poor prognosis. This study aims to assess whether plasma osteopontin was …

Biomarkers in mesothelioma

DT Arnold, NA Maskell - Annals of Clinical Biochemistry, 2018 - journals.sagepub.com
Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to
diagnose and monitor. Numerous studies have attempted to identify a blood-or pleural fluid …

Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide …

M Faria, MS Halquist, M Yuan, W Mylott Jr… - … of Chromatography B, 2015 - Elsevier
Human osteopontin (hOPN) is a secreted plasma protein which is elevated in various
cancers and is indicative of poor prognosis. Here we describe investigations involving an …

SPP1 promotes radiation resistance through JAK2/STAT3 pathway in esophageal carcinoma

M Wang, X Sun, H Xin, Z Wen, Y Cheng - Cancer Medicine, 2022 - Wiley Online Library
Background Therapeutic resistance to radiotherapy is one of the major obstacles in clinical
practice that significantly affect the therapeutic efficiency and prognosis of human …