The reception and integration of the plethora of signals a cell receives from its
microenvironment determines the cell's fate. CD44 functions as a receptor for hyaluronan …

Hyaluronic acid (HA), is a glycosaminoglycan comprised of repeating disaccharide units of
N-acetyl-d-glucosamine and d-glucuronic acid. HA is synthesized by hyaluronan synthases …

Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44
are crucial events that regulate the onset and progression of tumors. The intracellular …

Currently, a majority of cancer treatment strategies are based on the removal of tumor mass
mainly by surgery. Chemical and physical treatments such as chemo-and radiotherapies …

Now-a-days, the polysaccharides are extensively employed for the delivery of small-
molecule drugs ascribed to their excellent biocompatibility, biodegradability and …

Immunotherapy methods using potential tumor microenvironment modulators have elicited
durable therapeutic responses in cancer treatment. Immune checkpoint molecule …

Based on the overexpression of specific receptors on tumor cells, active targeting
nanomedicines have been developed with the ability to efficiently deliver imaging agents in …

Nanoparticles (NPs) that permit active targeting promise to play a key role in cancer therapy
moving forward. However, in order to successfully advance into clinic, these delivery …

Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression,
metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain …

Polymer therapeutics encompasses polymer–drug conjugates that are nano-sized,
multicomponent constructs already in the clinic as antitumor compounds, either as single …