[HTML][HTML] Application of multiple omics to understand postoperative delirium pathophysiology in humans
SM Vasunilashorn, ST Dillon, ER Marcantonio… - Gerontology, 2023 - karger.com
Delirium, an acute change in cognition, is common, morbid, and costly, particularly among
hospitalized older adults. Despite growing knowledge of its epidemiology, far less is known …
hospitalized older adults. Despite growing knowledge of its epidemiology, far less is known …
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications
Abstract Background Delirium and Alzheimer's disease (AD) are common causes of
cognitive dysfunction among older adults. These neurodegenerative diseases share a …
cognitive dysfunction among older adults. These neurodegenerative diseases share a …
Development and external validation of a delirium prediction model for hospitalized patients with coronavirus disease 2019
Background The coronavirus disease 2019 pandemic has placed unprecedented stress on
health systems and has been associated with elevated risk for delirium. The convergence of …
health systems and has been associated with elevated risk for delirium. The convergence of …
Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
YT Deng, BS Wu, L Yang, XY He, JJ Kang… - Nature Human …, 2024 - nature.com
While numerous genomic loci have been identified for neuropsychiatric conditions, the
contribution of protein-coding variants has yet to be determined. Here we conducted a large …
contribution of protein-coding variants has yet to be determined. Here we conducted a large …
Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients
M Heinrich, M Sieg, J Kruppa, P Nürnberg… - BMC medical …, 2021 - Springer
Background Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD)
are frequent and serious complications after surgery. We aim to investigate the association …
are frequent and serious complications after surgery. We aim to investigate the association …
Towards experimental models of delirium utilizing zebrafish
GO Maslov, KN Zabegalov, KA Demin… - Behavioural Brain …, 2023 - Elsevier
Delirium is an acute neuropsychiatric syndrome characterized by impaired behavior and
cognition. Although the syndrome has been known for millennia, its CNS mechanisms and …
cognition. Although the syndrome has been known for millennia, its CNS mechanisms and …
[HTML][HTML] A review of biomarkers in Delirium Superimposed on Dementia (DSD) and their clinical application to personalized treatment and management
S Jahangir, M Allala, AS Khan, VEM Arce, A Patel… - Cureus, 2023 - ncbi.nlm.nih.gov
Delirium superimposed on dementia (DSD) occurs when patients with pre-existing dementia
develop delirium. This complication causes patients to become impaired, posing safety …
develop delirium. This complication causes patients to become impaired, posing safety …
Longitudinal validation of an electronic health record delirium prediction model applied at admission in COVID-19 patients
Objective To validate a previously published machine learning model of delirium risk in
hospitalized patients with coronavirus disease 2019 (COVID-19). Method Using data from …
hospitalized patients with coronavirus disease 2019 (COVID-19). Method Using data from …
Exploration of key drug target proteins highlighting their related regulatory molecules, functional pathways and drug candidates associated with delirium: evidence …
Background Delirium is a prevalent neuropsychiatric medical phenomenon that causes
serious emergency outcomes, including mortality and morbidity. It also increases the …
serious emergency outcomes, including mortality and morbidity. It also increases the …