Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in
which β‐catenin drives the expression of certain genes as a consequence of the trigger …

Mutations in components of the Wnt pathways are a frequent cause of many human
diseases, particularly cancer. Despite the fact that a causative link between aberrant Wnt …

Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and
drug resistance. CIN is driven by chromosome segregation errors and a tolerance …

The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …

Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical
contributions to tumor initiation, malignant tumor progression and metastasis formation have …

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes.
They have been proposed as therapeutic targets to diminish Wnt signaling output in …

Accelerated dental pulp mineralization is a common complication in avulsed/luxated teeth,
although the mechanisms underlying this remain unclear. We hypothesized that hypoxia …

Wnt-stimulated β-catenin transcriptional regulation is necessary for the development of most
organs, including teeth. Bcl9 and Bcl9l are tissue-specific transcriptional cofactors that …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent
advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The …

BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional
complex and contribute critically to upholding the high WNT signaling level required for …