Schiff base 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide up-regulates the antioxidant status and inhibits the progression of Ehrlich solid tumor in mice

HA Aboseada, MM Hassanien, IH El-Sayed… - Biochemical and …, 2021 - Elsevier
Cisplatin is an approved cancer therapeutic drug used to treat many solid tumors but its
accumulation in the kidney, which causes nephrotoxicity, limits its clinical use. Therefore …

Glycine protects against doxorubicin-induced heart toxicity in mice

MI Shosha, FZ El-Ablack, EA Saad - Amino Acids, 2023 - Springer
Doxorubicin (DOXO) is a well-known cancer chemotherapeutic. However, its toxic effect on
the heart limits its clinical application. This study aimed to assess the effectiveness of glycine …

MUC7 VNTR polymorphism and association with bronchial asthma in Egyptian children

EA Saad, AM Elsaid, RMS Shoaib, KF Megahed… - Scientific Reports, 2022 - nature.com
Overproduction of mucins in the airways donates largely to airway blockage in asthma
patients. Glycoprotein MUC7 plays a role in the clearance of bacteria and has anti …

A newly synthesized derivative and a natural parent molecule: Which would be more beneficial as a future antitumor candidate? Docking and in vivo study

EA Saad, F Zahran, FZ El-Ablack… - Applied Biochemistry and …, 2022 - Springer
Seeking for new effectual anticancer drugs is of great importance. In this study, a newly
synthesized and well-characterized chromene derivative (ethyl 2-amino-4-phenyl-4H-benzo …

The new iron (III) 3‐oxo‐N‐(pyridin‐2‐yl) butanamide complex promotes Ehrlich solid tumor regression in mice via induction of apoptosis

EA Saad, SA Elsayed, MM Hassanien… - Applied …, 2020 - Wiley Online Library
Currently used chemotherapeutic drugs had serious adverse effects eg myelo‐suppression,
anemia and nephrotoxicity. Thus, developing new alternatives is of great importance. We …

Synthesis, characterization, and antitumor activity of a new iron-rifampicin complex: a novel prospective antitumor drug

EA Saad, HA Kiwan, MM Hassanien… - Journal of Drug Delivery …, 2020 - Elsevier
Rifampicin is a semi-synthetic derivative of rifamycin. It has a broad antibacterial activity. Iron
is the most plentiful transition metal in human body. It is a crucial nutrient needed for …

Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 …

M Abomosallam, BM Hendam, AA Abdallah… - …, 2024 - Springer
Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases
on grapes, stone fruits, cucurbits, and strawberries. Still, it leaves residues on treated crops …

[HTML][HTML] HCl-induced acute lung injury: a study of the curative role of mesenchymal stem/stromal cells and cobalt protoporphyrin

RA El-Shahat, RS El-Demerdash, EA Saad - Journal of Genetic …, 2021 - Elsevier
Background This study was designed to investigate bone marrow mesenchymal
stem/stromal cells (BM-MSCs) and cobalt protoporphyrin (CoPP) curable effects on HCl …

Antidiabetic activity of cobalt–quercetin complex: A new potential candidate for diabetes treatment

MM Hassanien, EA Saad… - Journal of Applied …, 2020 - japsonline.com
The development of effective, available, safe, and less costly antidiabetic synthetic
preparations based on natural products is of quite interest. To our knowledge, the flavonoid …

Biochemical and histopathological evaluations of chronic renal failure rats treated with pluripotent human stem cells

SAH Habib, AI Alalawy, EA Saad… - Brazilian Journal of …, 2022 - SciELO Brasil
Regeneration of damaged kidney cells using stem cells is the current research approach in
the treatment of chronic renal failure (CRF). In the present study, the histopathological and …