Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …

Adolescence is a time of continued brain maturation, particularly in limbic and cortical
regions, which undoubtedly plays a role in the physiological and emotional changes …

Adolescent development is associated with major changes in emotional and cognitive
functions, as well as a rise in stress-related psychological disorders such as anxiety and …

In this paper, we provide an overview of how the maturation of specific brain regions and
stress exposure during windows of vulnerability initiate a series of events that render …

Pain in infancy influences pain reactivity in later life, but how and why this occurs is poorly
understood. Here we review the evidence for developmental plasticity of nociceptive …

Adolescence is a transitional period between childhood and adulthood that encompasses
vast changes within brain systems that parallel some, but not all, behavioral changes …

An adverse maternal hormonal environment during pregnancy can be associated with
abnormal brain growth. Subtle changes in fetal brain development have been observed …

Adverse life events are associated with a wide range of psychopathology, including an
increased risk for substance abuse. In this review, we focus on the inter-relationship …

Modifications in neuroendocrine function are a hallmark of pubertal development. These
changes have many short-and long-term implications for the physiological and …