Cardiopulmonary bypass (CPB) has allowed for significant surgical advancements, but
accompanying risks can be significant and must be expertly managed. One of the foremost …

Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood
loss and allogeneic red blood cell transfusion in several clinical settings. With a growing …

Importance Red blood cell transfusion is a common medical intervention with benefits and
harms. Objective To provide recommendations for use of red blood cell transfusion in adults …

Abstract Purpose of Review Multiple guidelines and recommendations have been written to
address the perioperative management of antiplatelet and anticoagulant drugs. In this …

Inherited and acquired coagulopathy are frequently associated with major bleeding in
severe trauma, cardiac surgery with cardiopulmonary bypass, and postpartum hemorrhage …

Viscoelastic coagulation tests have been increasingly used for hemostasis management in
cardiac surgery. The ClotPro system is a novel viscoelastic device based on principles of …

Viscoelastic tests provide a dynamic assessment of coagulation, by exploring the time to clot
formation and the clot strength. Using specific activators or inhibitors, additional factors can …

Viscoelastic assays (VEAs) that include thromboelastography and rotational
thromboelastometry add value to the investigation of coagulopathies and goal-directed …

Optimized acute bleeding management requires timely and reliable laboratory testing to
detect and diagnose coagulopathies and guide transfusion therapy. Conventional …

From the aHarefield Hospital Royal Brompton and Harefield Hospitals, Imperial College
London, London, United Kingdom, Semmelweis University, Budapest, Hungary; bUniversity …