Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

Smoking-induced lung diseases were extremely rare prior to the 20th century. With
commercialization and introduction of machine-made cigarettes, worldwide use skyrocketed …

Non-small cell lung cancer (NSCLC) is the major form of lung cancer, with adenocarcinoma
(LUAD) and squamous cell carcinoma (LUSC) being its major subtypes. Smoking alone …

Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

Microcystins are highly toxic cyanotoxins responsible for plant, animal and human
poisoning. Exposure to microcystins, mainly through drinkable water and contaminated food …

Simple Summary GBM is a highly heterogeneous tumor owing to incredible cellular plasticity
and adaptation to hypoxia, nutrient availability and therapy. This plasticity is in part due to …

Respiratory syncytial viral (RSV) infections are a frequent cause of chronic obstructive
pulmonary disease (COPD) exacerbations, which are a major factor in disease progression …

SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the
increased expression of which correlates with poor prognosis in various types of cancer. In …

Rationale: CTSS (cathepsin S) is a cysteine protease that is observed at higher
concentrations in BAL fluid and plasma of subjects with chronic obstructive pulmonary …