Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive
complex 2 (PRC2), catalyzes the methylation of lysine 27 of histone H3 (H3K27) up to its …

The RAS isoforms are frequently mutated in many types of human cancers, including
PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle …

Skeletal muscle regeneration is initiated by satellite cells, a population of adult stem cells
that reside in the muscle tissue. The ability of satellite cells to self-renew and to differentiate …

Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …

Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood, and despite
clinical advances, subsets of these patients continue to suffer high levels of morbidity and …

Neuroblastoma is one of the commonest extra-cranial pediatric tumors, and accounts for
over 15% of all childhood cancer mortality. Risk stratification for children with neuroblastoma …

Soft tissue sarcomas (STSs) are an uncommon group of solid tumors that can arise
throughout the human lifespan. Despite their commonality as non-bony cancers that develop …

Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and
adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases …

Because colorectal cancer (CRC) stem-like cells (CCS-like cells) contribute to poor patient
prognosis, these cells are a potential target for CRC therapy. However, the mechanism …