Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …

Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal
inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis …

Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Abstract Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of
natural killer (NK) cells. The molecular basis for this duality of action remains unknown. Here …

Transforming growth factor–β (TGF-β) is a major immunosuppressive cytokine that maintains
immune homeostasis and prevents autoimmunity through its antiproliferative and anti …

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …

T‐bet and Eomes are T‐box transcription factors that drive the differentiation and function of
cytotoxic lymphocytes such as NK cells. Their DNA‐binding domains are highly similar …

Innate lymphoid cell (ILCs) subsets differentially populate various barrier and non-barrier
tissues, where they play important roles in tissue homeostasis and tissue-specific responses …

Type I interferons (IFNs) are known to mediate antitumor effects against several tumor types
and have therefore been commonly used in clinical anticancer treatment. However, how IFN …

Natural killer (NK) cells reject major histocompatibility complex class I (MHC-I)–deficient
bone marrow through direct cytotoxicity but not solid organ transplants devoid of MHC-I …