Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies

E Domingo, B Martínez-González… - Journal of …, 2023 - Am Soc Microbiol
Upon the emergence of SARS-CoV-2 in the human population, it was conjectured that for
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …

Recombination in positive-strand RNA viruses

H Wang, X Cui, X Cai, T An - Frontiers in microbiology, 2022 - frontiersin.org
RNA recombination is a major driver of genetic shifts tightly linked to the evolution of RNA
viruses. Genomic recombination contributes substantially to the emergence of new viral …

Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

E Jaworski, RM Langsjoen, B Mitchell, B Judy… - Elife, 2021 - elifesciences.org
High-throughput genomics of SARS-CoV-2 is essential to characterize virus evolution and to
identify adaptations that affect pathogenicity or transmission. While single-nucleotide …

Foot-and-mouth disease virus interserotypic recombination in superinfected carrier cattle

I Fish, C Stenfeldt, E Spinard, GN Medina, PA Azzinaro… - Pathogens, 2022 - mdpi.com
Viral recombination contributes to the emergence of novel strains with the potential for
altered host range, transmissibility, virulence, and immune evasion. For foot-and-mouth …

Heterologous RNA Recombination in the Cystoviruses φ6 and φ8: A Mechanism of Viral Variation and Genome Repair

P Gottlieb, A Alimova - Viruses, 2022 - mdpi.com
Recombination and mutation of viral genomes represent major mechanisms for viral
evolution and, in many cases, moderate pathogenicity. Segmented genome viruses …

Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains

E Spinard, I Fish, PA Azzinaro, M Rodriguez-Calzada… - Viruses, 2023 - mdpi.com
Codon deoptimization (CD) has been recently used as a possible strategy to derive foot-and-
mouth disease (FMD) live-attenuated vaccine (LAV) candidates containing DIVA markers …

Reply to Qu et al.,“Quasispecies are constantly selected through virus-encoded intracellular reproductive population bottlenecking”

E Domingo, B Martínez-González… - Journal of …, 2024 - Am Soc Microbiol
J. Han of our minireview on SARS-CoV-2 quasispecies recently published in the Journal of
Virology (1). Qu and colleagues disagree with one of our assertions about viral quasispecies …

[HTML][HTML] Uncovering Structural Plasticity of Enterovirus A through Deep Insertional and Deletional Scanning

W Bakhache, W Orr, L McCormick, PT Dolan - Research Square, 2024 - ncbi.nlm.nih.gov
Insertions and deletions (InDels) are essential sources of novelty in protein evolution. In
RNA viruses, InDels cause dramatic phenotypic changes contributing to the emergence of …

Nanopore-based direct RNA-sequencing reveals a high-resolution transcriptional landscape of porcine reproductive and respiratory syndrome virus

R Zhang, P Wang, X Ma, Y Wu, C Luo, L Qiu, B Zeshan… - Viruses, 2021 - mdpi.com
The TRS-mediated discontinuous transcription process is a hallmark of Arteriviruses.
Precise assessment of the intricate subgenomic RNA (sg mRNA) populations is required to …

RNA recombination: non-negligible factor for preventing emergence or reemergence of Senecavirus A

Y Li, T Liu, Y Zhang, X Duan, F Liu - Frontiers in Veterinary Science, 2024 - frontiersin.org
As an emerging virus, Senecavirus A (SVA) induces the vesicular disease in pigs. Clinical
cases initially show mild signs characterized by lethargy and lameness, usually followed by …