The importance of whole-genome duplication (WGD) for evolution is controversial. Whereas
some view WGD mainly as detrimental and an evolutionary dead end, there is growing …

Cellular decision-making guides complex development such as cell differentiation and
disease progression. Much of our knowledge about decision-making is derived from simple …

Aging is a leading cause of human morbidity and mortality, but efforts to slow or reverse its
effects are hampered by an incomplete understanding of its multi-faceted origins. Systems …

Precise control of gene expression is critical for biological research and biotechnology.
However, transient plasmid transfections in mammalian cells produce a wide distribution of …

Genetic noise together with genome duplication and volume changes during cell cycle are
significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these …

Noise-induced heterogeneity in gene expression is an inherent reality for cells. However, it
is not well understood how noise strength changes for a single gene while the host cell is …

Cellular decision-making arises from the expression of genes along a regulatory cascade,
which leads to a choice between distinct phenotypic states. DNA dosage variations, often …

In growing cells, protein synthesis and cell growth are typically not synchronous, and, thus,
protein concentrations vary over the cell division cycle. We have developed a theoretical …

Background Despite the development of various modeling approaches to predict gene
network activity, a time dynamic stochastic model taking into account real-time changes in …

Aging is a complex phenomenon of functional decay in a biological organism. Although the
effects of aging are readily recognizable in a wide range of organisms, the cause (s) of aging …