Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors

E Seigneur, J Wang, J Dai, J Polepalli… - Molecular psychiatry, 2021 - nature.com
Abstract Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are
expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 …

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

RP Tillage, NR Sciolino, NW Plummer… - Brain Structure and …, 2020 - Springer
Accumulating evidence indicates that disruption of galanin signaling is associated with
neuropsychiatric disease, but the precise functions of this neuropeptide remain largely …

An intersectional viral-genetic method for fluorescent tracing of axon collaterals reveals details of noradrenergic locus coeruleus structure

NW Plummer, DJ Chandler, JM Powell, EL Scappini… - ENeuro, 2020 - eneuro.org
Understanding the function of broadly projecting neurons depends on comprehensive
knowledge of the distribution and targets of their axon collaterals. While retrograde tracers …

Distribution of vasopressin 1a and oxytocin receptor protein and mRNA in the basal forebrain and midbrain of the spiny mouse (Acomys cahirinus)

JM Powell, K Inoue, KJ Wallace, AW Seifert… - Brain Structure and …, 2023 - Springer
The nonapeptide system modulates numerous social behaviors through oxytocin and
vasopressin activation of the oxytocin receptor (OXTR) and vasopressin receptor (AVPR1A) …

[HTML][HTML] The functional and anatomical characterization of three spinal output pathways of the anterolateral tract

H Chen, IH Bleimeister, EK Nguyen, J Li, AY Cui… - Cell reports, 2024 - cell.com
The nature of spinal output pathways that convey nociceptive information to the brain has
been the subject of controversy. Here, we provide anatomical, molecular, and functional …

The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex

KUS Islam, S Blaess - Frontiers in Neuroscience, 2024 - frontiersin.org
The prefrontal cortex (PFC) undergoes a protracted maturation process. This is true both for
local interneurons and for innervation from midbrain dopaminergic (mDA) neurons. In the …

Gene editing to generate versatile human pluripotent stem cell reporter lines for analysis of differentiation and lineage tracing

X Bao, MM Adil, R Muckom, JA Zimmermann… - Stem Cells, 2019 - academic.oup.com
Transcription factors (TFs) are potent proteins that control gene expression and can thereby
drive cell fate decisions. Fluorescent reporters have been broadly knocked into endogenous …

Viral tracing confirms paranigral ventral tegmental area dopaminergic inputs to the interpeduncular nucleus where dopamine release encodes motivated exploration

S Molas, R Zhao-Shea, TG Freels, AR Tapper - eneuro, 2023 - eneuro.org
Midbrain dopaminergic (DAergic) neurons of the ventral tegmental area (VTA) are engaged
by rewarding stimuli and encode reward prediction error to update goal-directed learning …

AxoDen: An algorithm for the automated quantification of axonal density in defined brain regions

RA Sandoval Ortega, E Li, O Joseph, PA Dufour… - bioRxiv, 2024 - biorxiv.org
The rodent brain contains 70,000,000+ neurons interconnected via complex axonal circuits
with varying architectures. Neural pathologies are often associated with anatomical changes …

DeepNeurite™: Identification of neurites from non‐specific binding of fluorescence probes through deep learning

KC Huang, S Lou, CC Wang… - FASEB …, 2022 - Wiley Online Library
The nervous system plays an important role in human health and disease, and the unique
morphologies of the neurons underlie its ability to interface with tissues and organs …