Memory T cells: strategies for optimizing tumor immunotherapy

Q Liu, Z Sun, L Chen - Protein & cell, 2020 - academic.oup.com
Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …

Models, mechanisms and clinical evidence for cancer dormancy

JA Aguirre-Ghiso - Nature Reviews Cancer, 2007 - nature.com
Patients with cancer can develop recurrent metastatic disease with latency periods that
range from years even to decades. This pause can be explained by cancer dormancy, a …

Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment

Y Zhu, Z Yang, Z Pan, Y Hao, C Wang, Z Dong, Q Li… - Science …, 2022 - science.org
Microwave ablation (MWA) as a local tumor ablation strategy suffers from posttreatment
tumor recurrence. Development of adjuvant biomaterials to potentiate MWA is therefore of …

Metronomic chemotherapy: new rationale for new directions

E Pasquier, M Kavallaris, N André - Nature reviews Clinical oncology, 2010 - nature.com
Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Cancer micrometastases

K Pantel, C Alix-Panabieres, S Riethdorf - Nature reviews Clinical …, 2009 - nature.com
Early spread of tumor cells is usually undetected by current imaging technologies. In
patients with cancer and no signs of overt metastases sensitive methods have been …

Dormant tumour cells, their niches and the influence of immunity

ET Goddard, I Bozic, SR Riddell, CM Ghajar - Nature cell biology, 2018 - nature.com
Despite increased focus on the clinical relevance of dormant metastatic disease, our
understanding of dormant niches, mechanisms underlying emergence from dormancy, and …

Immune-mediated dormancy: an equilibrium with cancer

MWL Teng, JB Swann, CM Koebel… - Journal of Leucocyte …, 2008 - academic.oup.com
This brief review discusses the role of the immune system in tumor development, covering a
history of cancer immunity and a summary of the concept of cancer immunoediting, including …

Tuning cancer fate: tumor microenvironment's role in cancer stem cell quiescence and reawakening

A Sistigu, M Musella, C Galassi, I Vitale… - Frontiers in …, 2020 - frontiersin.org
Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease

MS Sosa, A Avivar-Valderas, P Bragado, HC Wen… - Clinical cancer …, 2011 - AACR
Systemic minimal residual disease after primary tumor treatment can remain asymptomatic
for decades. This is thought to be due to the presence of dormant disseminated tumor cells …

Decoding melanoma metastasis

WE Damsky Jr, LE Rosenbaum, M Bosenberg - Cancers, 2010 - mdpi.com
Metastasis accounts for the vast majority of morbidity and mortality associated with
melanoma. Evidence suggests melanoma has a predilection for metastasis to particular …