Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Natural biomaterials are extensively used in tissue engineering due to their microstructure
interconnectivity and inherent bioactivity which mimics of natural extracellular matrix (ECM) …

The aberrant mechanical microenvironment in degenerated tissues induces misdirection of
cell fate, making it challenging to achieve efficient endogenous regeneration. Herein, a …

Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …

Collagen alignment is one of the key microarchitectural signatures of many pathological
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …

Stem cell injection is an effective approach for treating diabetic wounds; however, shear
stress during injections can negatively affect their stemness and cell growth. Cell‐laden …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …

Chinese herbal medicine (CHM) evolved through thousands of years of practice and was
popular not only among the Chinese population, but also most countries in the world …

Chronic diabetic foot ulcers (DFUs) are an important clinical issue faced by clinicians
despite the advanced treatment strategies consisting of wound debridement, off-loading …