Though results remain mixed, the many ongoing trials will provide more conclusive
evidence within the next few years and help to optimize interventions. Continued …

Abstract Background and Aims The COVID‐19 pandemic has presented significant
challenges to clinical research, necessitating the adoption of innovative and remote …

INTRODUCTION We investigated the effectiveness of a multidomain intervention to preserve
cognitive function in older adults at risk for dementia in Germany in a cluster‐randomized …

Background The COVID-19 pandemic has major influence on lifestyle and mental health,
which might affect brain-health and increase the risk of cognitive decline, particularly in older …

Aim To evaluate the effects of a physical activity programme on sedentary behaviour and
physical activity in ambulant individuals with Rett syndrome (RTT). Method In this multicentre …

Background Due to the time-dependent effect of specific risk factors for dementia,
multidomain interventions based on a life-course model might achieve optimal preventive …

The global pandemic of coronavirus disease 2019 (COVID‐19) affected many aspects of
randomized controlled trials, including recruiting and screening participants. The purpose of …

Introduction Social activities are important for health and act as a driver of cognitive reserve
during aging. In this perspective paper, we describe challenges and outline future (research) …

INTRODUCTION Dementia risk scores constitute promising surrogate outcomes for lifestyle
interventions targeting cognitive function. We investigated whether dementia risk, assessed …

Background Reversal of cognitive frailty through a multidomain intervention is desirable to
prevent dementia. AGELESS Trial was conducted to determine the effectiveness of a …