CCR7 as a therapeutic target in Cancer

A Salem, M Alotaibi, R Mroueh, HA Basheer… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The CCR7 chemokine axis is comprised of chemokine ligand 21 (CCL21) and chemokine
ligand 19 (CCL19) acting on chemokine receptor 7 (CCR7). This axis plays two important …

Multiple roles of glycans in hematological malignancies

X Pang, H Li, F Guan, X Li - Frontiers in oncology, 2018 - frontiersin.org
The three types of blood cells (red blood cells for carrying oxygen, white blood cells for
immune protection, and platelets for wound clotting) arise from hematopoietic …

The phosphorylation of CCR6 on distinct Ser/Thr residues in the carboxyl terminus differentially regulates biological function

MY Lu, SS Lu, SL Chang, F Liao - Frontiers in immunology, 2018 - frontiersin.org
CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand,
CCL20 and is primarily expressed by leukocytes. Upon ligand binding, CCR6 activates Gαi …

The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer

ASAS Salem - 2021 - bradscholars.brad.ac.uk
Chemokines are a family of chemotactic cytokines that play a multifaceted role in human
biology. Chemokine receptor CCR7, activated by its ligands CCL19 & CCL21, is known to …