Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and
chronic inflammation, involving multiple cellular dysfunctions and tissue lesions. The non …

Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA),
but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections …

The healing of chronic diabetic wounds remains a formidable challenge in modern times. In
this study, a novel traditional Chinese medicine microneedle patch was designed based on …

Osteoarthritis (OA) represents an enduring and widespread global burden, causing
significant morbidity and disability, whose pathology is characterized by persistent …

Diabetic ulcers (DUs) are characterized by massive biofilm formation, long-term
inflammatory infiltration, and difficulty in healing. Electrical stimulation (ES) applied through …

Osteoarthritis (OA) is a musculoskeletal disorder affecting∼ 500 million people worldwide.
Metformin (MET), as an oral hypoglycemic drug approved by the Food and Drug …

Cartilage injuries are escalating worldwide, particularly in aging society. Given its limited self-
healing ability, the repair and regeneration of damaged articular cartilage remain formidable …

Ulcerative colitis (UC) is a chronic recurrent disease of the gastrointestinal tract. Though the
exact etiology is still unknown, inflamed enterocytes, activated macrophages, and the …

As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very
limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden …