The rise of the “Top Down” method in the field of mass spectrometry-based proteomics has
ushered in a new age of promise and challenge for the characterization and identification of …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

At currently achievable Fourier transform ion cyclotron resonance broadband mass
spectrometry resolving power (m/Δ m 50%> 350 000 for 200< m/z< 1000), it would be …

Molecular formulas have been assigned for 4626 individual Suwannee River fulvic acids
based on accurate mass measurements from ions generated by electrospray ionization and …

This article describes a new algorithm for charge state determination and deconvolution of
electrospray ionization (ESI) mass-to-charge ratio spectra. The algorithm (Zscore) is based …

A Liaohe crude oil was separated as saturates, aromatics, resins, and asphaltenes (SARA)
and neutral nitrogen fractions. The crude oil and its subfractions were analyzed by negative …

Because of the increasing importance of heavy and unconventional crude oil as an energy
source, there is a growing need for petroleomics: the pursuit of more complete and detailed …

Here a fully automated computer algorithm is applied to complex mass spectra of peptides
and proteins. This method uses a subtractive peak finding routine to locate possible isotopic …

Although crude acids are minor constituents in petroleum, they have significant implications
for crude oil geochemistry, corrosion, and commerce. We have previously demonstrated that …

Mass spectrometry is well-suited for complex mixture analysis, because unlike other types of
spectroscopy, the number of mass spectral peaks per analyte is of order one. Here, we …