Development and longevity of naturally acquired antibody and memory B cell responses against Plasmodium vivax infection

P Thawornpan, P Kochayoo, ZZ Salsabila… - PLOS Neglected …, 2024 - journals.plos.org
Plasmodium vivax malaria causes significant public health problems in endemic regions.
Considering the rapid spread of drug-resistant parasite strains and the development of …

Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

FB Ntumngia, SK Kolli, P Annamalai Subramani… - Scientific Reports, 2024 - nature.com
In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite
invasion of erythrocytes and disease development. Very few studies have evaluated pre …

[HTML][HTML] Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses

C Schäfer, N Dambrauskas, LM Reynolds… - Cell Host & Microbe, 2021 - cell.com
Latent forms of Plasmodium vivax, called hypnozoites, cause malaria relapses from the liver
into the bloodstream and are a major obstacle to malaria eradication. To experimentally …

A universal vaccine candidate against Plasmodium vivax malaria confers protective immunity against the three PvCSP alleles

AM Gimenez, AM Salman, RF Marques… - Scientific Reports, 2021 - nature.com
Malaria is a highly prevalent parasitic disease in regions with tropical and subtropical
climates worldwide. Among the species of Plasmodium causing human malaria, P. vivax is …

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

I Kucharska, L Hossain, D Ivanochko, Q Yang… - Elife, 2022 - elifesciences.org
Malaria is a global health burden, with Plasmodium falciparum (Pf) and Plasmodium vivax
(Pv) responsible for the majority of infections worldwide. Circumsporozoite protein (CSP) is …

Construction, Expression, and Evaluation of the Naturally Acquired Humoral Immune Response against Plasmodium vivax RMC-1, a Multistage Chimeric Protein

AS Matos, IF Soares, BO Baptista… - International Journal of …, 2023 - mdpi.com
The PvCelTOS, PvCyRPA, and Pvs25 proteins play important roles during the three stages
of the P. vivax lifecycle. In this study, we designed and expressed a P. vivax recombinant …

Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

P Thawornpan, J Nicholas, C Malee… - PLoS Neglected …, 2024 - journals.plos.org
Background P. vivax malaria is a major global health burden hindering social and economic
development throughout many tropical and sub-tropical countries. Pre-erythrocytic (PE) …

[HTML][HTML] Circumsporozoite Protein from Plasmodium vivax and Its Relationship to Human Malaria

LM Storti-Melo, GC Cassiano… - New Advances in …, 2022 - intechopen.com
The circumsporozoite surface protein (CSP) is the most abundant polypeptide in the
sporozoite covering. This protein is involved in the motility and invasion of the sporozoite …

Evaluation of the Humoral Immune Responses to Plasmodium vivax Circumsporozoite Protein (CSP)-based Pre-Erythrocytic Vaccine Candidates

J Esquenazi - 2023 - search.proquest.com
Malaria, caused by the apicomplexan Plasmodium spp., is a major public health issue that
impacts over one-third of the world's population, with Plasmodium vivax accounting for over …

Producción de bácmidos recombinantes del ectodominio de la proteína del circumsporozoito (EcCSP) y de la región ll de la proteína de Unión al Duffy (DBP-RII) de …

MC Beltrán Pérez - 2021 - repositorio.unicolmayor.edu.co
Plasmodium vivax es una de las especies más ampliamente distribuidas a nivel mundial,
pero desafortunadamente no se ha podido investigar a profundidad los mecanismos de …