As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

Tissue-resident memory T cells (TRM cells) in the airways mediate protection against
respiratory infection. We characterized TRM cells expressing integrin αE (CD103) that reside …

The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …

How early events in effector T cell (T EFF) subsets tune memory T cell (T MEM) responses
remains incompletely understood. Here, we systematically investigated metabolic factors in …

Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …

T cells, the critical immune cells of the adaptive immune system, are often dysfunctional in
Alzheimer's disease (AD) and are involved in AD pathology. Reports highlight …

Resident memory T cells (T RM) reside in the lung epithelium and mediate protective
immunity against respiratory pathogens. Although lung CD8+ T RM have been extensively …

A fundamental benefit of immunological memory is the ability to respond in an enhanced
manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T …

There are numerous mechanisms by which glioblastoma cells evade immunological
detection, underscoring the need for strategic combinatorial treatments to achieve …