Alzheimer's disease (AD) is a progressive neuronal/cognitional dysfunction, leading to
disability and death. Despite advances in revealing the pathophysiological mechanisms …

Alzheimer's disease (AD) is the most prevalent form of dementia affecting millions of people
worldwide. It is a progressive, irreversible, and incurable neurodegenerative disorder that …

ABSTRACT Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that
protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer's …

Neuroinflammation in response to environmental stressors is an important common pathway
in a number of neurological and psychiatric disorders. Responses to immune-mediated …

Neurodegenerative disease is an umbrella term for different conditions which primarily affect
the neurons in the human brain. In the last century, significant research has been focused on …

Aims Dauricine has been found that has significant neuroprotective effect on Alzheimer's
disease (AD), but the mechanism is unclear, so we further investigated the possible …

For Alzheimer's disease (AD), there is still no effective treatment strategy. Pinoresinol
diglucoside (PDG) is one of the major lignans isolated from Eucommia ulmoides. It is …

Oxidative stress has been implicated in the etiology of Parkinson's disease (PD). Molecules
non-covalently binding to the Keap1–Nrf2 complex could be a promising therapeutic …

Human civilization has been dependent on plants for food and medicinal purposes since
prehistoric times. In history, there has been a plethora of evidence highlighting the effective …

Drug development for Alzheimer's disease, the leading cause of dementia, has been a long-
standing challenge. Saponins, which are steroid or triterpenoid glycosides with various …