Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

Endocrine factors and signals of fetal organ maturation are reported determinants of birth
timing. To test the hypothesis that paracrine signaling by exosomes are key regulators of …

The cervix is the essential gatekeeper for birth. Incomplete cervix remodeling contributes to
problems with delivery at or post-term while preterm birth is a major factor in perinatal …

Preterm birth affects approximately 1 out of every 10 births in the United States, leading to
high rates of mortality and long-term negative health consequences. To investigate the …

The interferon (IFN)-mediated innate immune response is the first line of defense against
viruses. However, an IFN-stimulated gene, the adenosine deaminase acting on RNA 1 …

Inflammation contributes to nearly 4 million global premature births annually. Here, we used
a mouse model of intrauterine inflammation to test clinically used formulations, as well as …

Gasotransmitters are endogenous small gaseous messengers exemplified by nitric ox ide
(NO), carbon monoxide (CO), and hydrogen sulfide (H2S or sulfide). Gasotransmitters are …

The prostaglandin E2 receptor, EP2, plays an important role in physiology and in a variety of
pathological conditions. Studies indicate that EP2 is pro-inflammatory in chronic peripheral …

Moringa oleifera leaf, a popular medicinal and edible plant in Kenya communities, exhibits
good anti-inflammatory effects. In present study, its anti-inflammatory mechanisms were first …