In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …

The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS) that affects approximately 2.8 million people worldwide. In …

Multiple sclerosis (MS) is a severe immune-mediated neurological disease characterized by
neuroinflammation, demyelination, and axonal degeneration in the central nervous system …

Elevated levels of Chitinase-3-like protein-1 (CHI3L1) in cerebrospinal fluid have previously
been linked to inflammatory activity and disease progression in multiple sclerosis (MS) …

Despite current therapeutic strategies for immunomodulation and relief of symptoms in
multiple sclerosis (MS), remyelination falls short due to dynamic neuropathologic …

Activation of microglia and/or astrocytes often releases proinflammatory molecules as critical
pathogenic mediators that can promote neuroinflammation and secondary brain damages in …

Multiple sclerosis (MS) is a chronic central nervous system demyelinating disease of
autoimmune originate. Complement C1q, a complex glycoprotein, mediates a variety of …

Background Multiple sclerosis (MS) is the most frequent non-traumatic neurological
debilitating disease among young adults with no cure. Over recent decades, efforts to treat …

Background Multiple sclerosis (MS) is an inflammatory chronic autoimmune and
neurodegenerative disorder of the brain and spinal cord, resulting in loss of motor, sensorial …