Hepatitis C virus, a major human pathogen, produces infectious virus particles with several
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid
synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious …

Positive-strand RNA viruses replicate in close association with rearranged intracellular
membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus …

All positive strand RNA viruses are known to replicate their genomes in close association
with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family …

Viral nucleic acids often trigger an innate immune response in infected cells. Many viruses,
including hepatitis C virus (HCV), have evolved mechanisms to evade intracellular …

Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To
gain insight into host factor requirements for HCV replication, we performed a siRNA screen …

The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a
bewildering array of important human and animal diseases. Morphogenesis is the least …

Annexins constitute an evolutionary conserved multigene protein superfamily characterized
by their ability to interact with biological membranes in a calcium dependent manner. They …

ABSTRACT Enterovirus type 71 (EV71) causes hand, foot, and mouth disease (HFMD),
which is mostly self-limited but may be complicated with a severe to fatal neurological …

Background & Aims Direct-acting antivirals that target nonstructural protein 5A (NS5A), such
as daclatasvir, have high potency against the hepatitis C virus (HCV). They are promising …