Crosstalk between the nervous system and tumor microenvironment: functional aspects and potential therapeutic strategies

L Wang, J Ge, H Han, Y Jia, Y Qin - Cancer Letters, 2024 - Elsevier
Recent advancements in understanding the tumor microenvironment (TME) have
highlighted the critical role of the nervous system in cancer progression. This review …

A review on targeting tumor microenvironment: The main paradigm shift in the mAb-based immunotherapy of solid tumors

A Aghanejad, SF Bonab, M Sepehri… - International journal of …, 2022 - Elsevier
Monoclonal antibodies (mAbs) as biological macromolecules have been remarked the large
and growing pipline of the pharmaceutical market and also the most promising tool in …

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and …

IMM Othman, ZM Alamshany, NY Tashkandi… - RSC …, 2022 - pubs.rsc.org
Deregulation of various protein kinases is considered as one of the important factors
resulting in cancer development and metastasis, thus multi-targeting the kinase family is one …

VEGF signaling: Role in angiogenesis and beyond

P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Exploring the past, present, and future of anti-angiogenic therapy in glioblastoma

AB Zhang, K Mozaffari, B Aguirre, V Li, R Kubba… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma is the most common malignant primary brain tumor. Despite
technological advancements and modern therapeutic agents used for treatment, the …

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy: Special Collection: Aggregation‐Induced Processes and Functions

Y Liu, S Xu, Q Lyu, Y Huang, W Wang - Aggregate, 2024 - Wiley Online Library
Nowadays, cancer has become the leading cause of death worldwide, driving the need for
effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) has been …

Inhibiting angiogenesis by anti-cancer saponins: from phytochemistry to cellular signaling pathways

MB Majnooni, S Fakhri, SM Ghanadian, G Bahrami… - Metabolites, 2023 - mdpi.com
Saponins are one of the broadest classes of high-molecular-weight natural compounds,
consisting mainly of a non-polar moiety with 27 to 30 carbons and a polar moiety containing …

Endostatin and cancer therapy: a novel potential alternative to anti-VEGF monoclonal antibodies

G Méndez-Valdés, F Gómez-Hevia, J Lillo-Moya… - Biomedicines, 2023 - mdpi.com
Angiogenesis is a physiological process that consists of the formation of new blood vessels
from preexisting ones. Angiogenesis helps in growth, development, and wound healing …

Strategies for active tumor targeting-an update

D Vyas, M Patel, S Wairkar - European Journal of Pharmacology, 2022 - Elsevier
A complete cure for cancer is still the holy grail for scientists. The existing treatment of cancer
is primarily focused on surgery, radiation and conventional chemotherapy. However …

Canagliflozin modulates hypoxia-induced metastasis, angiogenesis and glycolysis by decreasing HIF-1α protein synthesis via AKT/mTOR pathway

J Luo, P Sun, X Zhang, G Lin, Q Xin, Y Niu… - International Journal of …, 2021 - mdpi.com
The microenvironment plays a vital role in tumor progression, and hypoxia is a typical
microenvironment feature in nearly all solid tumors. In this study, we focused on elucidating …