▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …

The brain occupies a special hierarchical position in the organism. It is separated from the
general circulation by the blood-brain barrier, has high energy consumption and a low …

Ligand-induced receptor oligomerization is an established mechanism for receptor-tyrosine
kinase activation. However, numerous receptor-tyrosine kinases are expressed in …

The nerve growth factor (NGF) belongs to the neurotrophin family and induces its effects
through activation of 2 distinct receptor types: the tropomyosin-related kinase A (TrkA) …

Nerve growth factor (NGF) promotes neuronal survival and differentiation and stimulates
neurite outgrowth. NGF is synthesized as a precursor, proNGF, which undergoes post …

OBJECTIVE—Recently we have shown that diabetes-induced retinal neurodegeneration
positively correlates with oxidative stress and peroxynitrite. Studies also show that …

This review deals with the receptor interactions of neurotrophic factors, focusing on the
neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic …

There is growing evidence that nerve growth factor (NGF) may function as a mediator of
persistent pain states. We have identified a novel nonpeptidic molecule, ALE-0540, that …

Nerve growth factor (NGF) binding to its receptors TrkA and p75 NTR enhances the survival,
differentiation, and maintenance of neurons. Recent studies have suggested that NGF …