Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these
factors affect the structure and function of the epidermis and dermis. Histologically, aging …

There is increasing evidence that skin aging is significantly enforced by the accumulation of
senescent dermal fibroblasts. Various stressors damaging macromolecules inside and …

Cellular senescence and aging result in a reduced ability to manage persistent types of
inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is …

Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …

Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …

The aging of the skin is the most visible and obvious manifestation of organismal aging and
may serve as a predictor of life expectancy and health. It is, however, also the human desire …

Skin is the largest organ in the body comprised of three different layers including the
epidermis, dermis, and hypodermis. The dermis is mainly composed of dermal fibroblasts …

The increasingly aging society led to a rise in the prevalence of chronic wounds (CWs),
posing a significant burden to public health on a global scale. One of the key features of …

The nuclear factor-κB (NF-κB) signaling pathway is one of the most well-studied pathways
related to inflammation, and its involvement in aging has attracted considerable attention. As …