Diazo groups have broad and tunable reactivity. That and other attributes endow diazo
compounds with the potential to be valuable reagents for chemical biologists. The presence …

Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

Aromatic polyketides have attractive biological activities and pharmacological properties.
Different from other polyketides, aromatic polyketides are characterized by their polycyclic …

The lomaiviticins are dimeric genotoxic metabolites that contain unusual
diazocyclopentadiene functional groups and 2–4 deoxyglycoside residues. Because only 6 …

Azaserine is a bacterial metabolite containing a biologically unusual and synthetically
enabling α‐diazoester functional group. Herein, we report the discovery of the azaserine …

Micromonospora, one of the most important actinomycetes genera, is well-known as the
treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth …

Colibactin is a secondary metabolite produced by certain strains of bacteria found in the
human gut. The presence of colibactin-producing bacteria has been correlated to colorectal …

Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the
clb genomic island that has a widespread distribution in pathogenic and commensal human …

Unprecedented Staudinger reaction modes of secondary phosphine oxides (SPO) and
organic azides are herein disclosed. By the application of various additives, selective …