Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Traditional cancer therapy methods, especially those directed against specific intracellular
targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity …

Lung cancer has been the most common and the leading cause of cancer deaths globally.
Besides clinicopathological observations and traditional molecular tests, the advent of …

As single-cell RNA sequencing (scRNA-seq) has emerged as a great tool for studying
cellular heterogeneity within the past decade, the number of available scRNA-seq datasets …

Gastric cancer (GC) is a common malignant tumor in the digestive tract and a major cause of
global cancer death. Due to the limited access to early screening, many patients are …

Examining tumor-associated macrophages in the immune microenvironment of non-small
cell lung cancer (NSCLC) is essential for gaining an understanding of the genesis and …

Immunotherapy has made great strides in the treatment of lung cancer, but a significant
proportion of patients still do not respond to treatment. Therefore, the identification of novel …

Protein phosphorylation plays a crucial role in regulating disease phenotypes and serves as
a key target for drug development. Mapping nanoscale‐to‐single‐cell samples can unravel …

Understanding the specific type of brain malignancy, source of brain metastasis, and
underlying transformation mechanisms can help provide better treatment and less harm to …

Background Immunotherapy has shown considerable promise in cancer treatment, yet only
a minority of osteosarcoma patients derive benefits from this approach. Hypoxia and lactate …