Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
Vaccination induces HIV broadly neutralizing antibody precursors in humans
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
Protein engineering strategies for rational immunogen design
TM Caradonna, AG Schmidt - npj Vaccines, 2021 - nature.com
Antibody immunodominance refers to the preferential and asymmetric elicitation of
antibodies against specific epitopes on a complex protein antigen. Traditional vaccination …
antibodies against specific epitopes on a complex protein antigen. Traditional vaccination …
Vaccination induces broadly neutralizing antibody precursors to HIV gp41
A key barrier to the development of vaccines that induce broadly neutralizing antibodies
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
[HTML][HTML] Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice
CA Cottrell, X Hu, JH Lee, P Skog, S Luo… - Science Translational …, 2024 - science.org
A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs).
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-
19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope …
19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope …
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly
neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the …
neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the …
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells
JH Lee, L Toy, JT Kos, Y Safonova, WR Schief… - NPJ vaccines, 2021 - nature.com
A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome
the hurdle of being able to activate naive precursor B cells encoding features within their …
the hurdle of being able to activate naive precursor B cells encoding features within their …