Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal
fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …

Blood biomarkers have great potential to advance clinical care and accelerate trials in
Alzheimer's disease (AD). Plasma phospho-tau181 (p-tau181) is a promising blood …

Objective In Alzheimer's disease, hyperphosphorylated tau is associated with formation of
insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are …

Slow-wave sleep (SWS) modulation in rodent models of Alzheimer's disease alters
extracellular amyloid burden. In Parkinson's disease (PD), SWS appears to be closely linked …

Sleep is a complex, highly regulated process essential for human health and wellbeing.
Increasingly, sleep–wake disturbance has been implicated in the pathogenesis of chronic …

Objective The glymphatic system is thought to be responsible for waste clearance in the
brain. As it is primarily active during sleep, different components of sleep, subjective sleep …

Importance Sleep disturbance is common among patients with neurodegenerative diseases.
Examining the subcortical neuronal correlates of sleep disturbances is important to …

Sleep is essential for human well-being, yet the quality and quantity of sleep reduce as age
advances. Older persons (> 65 years old) are more at risk of disorders accompanied and/or …

Accumulating evidence supports a link between sleep disorders, disturbed sleep, and
adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive …