Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …

Sophisticated behavioral paradigms partnered with the emergence of increasingly selective
techniques to target the basolateral amygdala (BLA) have resulted in an enhanced …

Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …

Corticostriatal circuitry supports flexible reward learning and emotional behavior from the
critical neurodevelopmental stage of adolescence through adulthood. It is still poorly …

Rationale Impairments in behavioral flexibility lie at the core of anxiety and obsessive-
compulsive disorders. Few studies, however, have investigated the neural substrates of …

There has been substantial research into the role of the amygdala in fear conditioning and
extinction of conditioned fear. The role of the amygdala in appetitive conditioning is relatively …

Intrinsic uncertainty in the reward environment requires the brain to run multiple models
simultaneously to predict outcomes based on preceding cues or actions, commonly referred …

The neural and psychological mechanisms of inhibitory control processes were investigated,
focusing on the cortico-basal ganglia circuits in rats and humans. These included …

Previous research employing modulation of 5-HT2C receptors (5-HT2CRs) in rodents has
identified a potential role in mediating cognitive flexibility. The work presented in this thesis …

Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …