Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms

RD Burke, SW Todd, E Lumsden… - Journal of …, 2017 - Wiley Online Library
Organophosphorus (OP) insecticides are pest‐control agents heavily used worldwide.
Unfortunately, they are also well known for the toxic effects that they can trigger in humans …

Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems

C Frye, E Bo, G Calamandrei, L Calza… - Journal of …, 2012 - Wiley Online Library
Some environmental contaminants interact with hormones and may exert adverse
consequences as a result of their actions as endocrine disrupting chemicals (EDCs) …

Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment

DL Eaton, RB Daroff, H Autrup, J Bridges… - Critical reviews in …, 2008 - Taylor & Francis
This review examines the large body of toxicological and epidemiological information on
human exposures to chlorpyrifos, with an emphasis on the controversial potential for …

Potential developmental neurotoxicity of pesticides used in Europe

M Bjørling-Poulsen, HR Andersen, P Grandjean - Environmental Health, 2008 - Springer
Pesticides used in agriculture are designed to protect crops against unwanted species, such
as weeds, insects, and fungus. Many compounds target the nervous system of insect pests …

Antioxidant and anti-inflammatory potential of thymoquinone and lycopene mitigate the chlorpyrifos-induced toxic neuropathy

M Aboubakr, SM Elshafae, EY Abdelhiee, SE Fadl… - Pharmaceuticals, 2021 - mdpi.com
CPF (chlorpyrifos) is an organophosphate pesticide used in agricultural and veterinary
applications. Our experiment aimed to explore the effects of thymoquinone (TQ) and/or …

Developmental neurotoxicity of succeeding generations of insecticides

Y Abreu-Villaça, ED Levin - Environment international, 2017 - Elsevier
Insecticides are by design toxic. They must be toxic to effectively kill target species of insects.
Unfortunately, they also have off-target toxic effects that can harm other species, including …

Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies

CJ Burns, LJ McIntosh, PJ Mink… - Journal of Toxicology …, 2013 - Taylor & Francis
Assessment of whether pesticide exposure is associated with neurodevelopmental
outcomes in children can best be addressed with a systematic review of both the human and …

Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds

IWT Selderslaghs, R Blust, HE Witters - Reproductive toxicology, 2012 - Elsevier
To anticipate to increased testing needs for reproductive toxicity and 3R approaches, we
studied zebrafish embryo/larva as an alternative for animal testing for developmental toxicity …

Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity …

TA Slotkin, FJ Seidler - Brain research bulletin, 2007 - Elsevier
Organophosphates affect mammalian brain development through a variety of mechanisms
beyond their shared property of cholinesterase inhibition. We used microarrays to …

Multifactorial origin of neurodevelopmental disorders: approaches to understanding complex etiologies

A De Felice, L Ricceri, A Venerosi, F Chiarotti… - Toxics, 2015 - mdpi.com
A significant body of evidence supports the multifactorial etiology of neurodevelopmental
disorders (NDDs) affecting children. The present review focuses on early exposure to …