Titin: a tunable spring in active muscle
K Nishikawa - Physiology, 2020 - journals.physiology.org
Muscle has conventionally been viewed as a motor that converts chemical to kinetic energy
in series with a passive spring, but new insights emerge when muscle is viewed as a …
in series with a passive spring, but new insights emerge when muscle is viewed as a …
Biomechanics, motor control and dynamic models of the soft limbs of the octopus and other cephalopods
Muscular hydrostats are organs composed entirely of packed arrays of incompressible
muscles and lacking any skeletal support. Found in both vertebrates and invertebrates, they …
muscles and lacking any skeletal support. Found in both vertebrates and invertebrates, they …
Titin force in muscle cells alters lattice order, thick and thin filament protein formation
Skeletal muscle force production is increased at longer compared to shorter muscle lengths
because of length-dependent priming of thick filament proteins in the contractile unit before …
because of length-dependent priming of thick filament proteins in the contractile unit before …
Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles
U Tahir, JA Monroy, NA Rice… - Journal of …, 2020 - journals.biologists.com
The active isometric force produced by muscles varies with muscle length in accordance
with the force–length relationship. Compared with isometric contractions at the same final …
with the force–length relationship. Compared with isometric contractions at the same final …
N2A titin: signaling hub and mechanical switch in skeletal muscle
Since its belated discovery, our understanding of the giant protein titin has grown
exponentially from its humble beginning as a sarcomeric scaffold to recent recognition of its …
exponentially from its humble beginning as a sarcomeric scaffold to recent recognition of its …
FAMOUS: a fast instrumental and computational pipeline for multiphoton microscopy applied to 3D imaging of muscle ultrastructure
We present a new instrumental and computational pipeline named FAMOUS: fast algorithm
for three-dimensional (3D) multiphoton microscopy of biomedical structures. This pipeline …
for three-dimensional (3D) multiphoton microscopy of biomedical structures. This pipeline …
Transcriptomic profiles of muscular dystrophy with myositis (mdm) in extensor digitorum longus, psoas, and soleus muscles from mice
Background Titinopathies are inherited muscular diseases triggered by genetic mutations in
the titin gene. Muscular dystrophy with myositis (mdm) is one such disease caused by a …
the titin gene. Muscular dystrophy with myositis (mdm) is one such disease caused by a …
Non-cross bridge viscoelastic elements contribute to muscle force and work during stretch-shortening cycles: evidence from whole muscles and permeabilized fibers
The sliding filament–swinging cross bridge theory of skeletal muscle contraction provides a
reasonable description of muscle properties during isometric contractions at or near …
reasonable description of muscle properties during isometric contractions at or near …
Assessment and modelling of the activation‐dependent shift in optimal length of the human soleus muscle in vivo
S Bohm, A Schroll, F Mersmann… - The Journal of …, 2024 - Wiley Online Library
Previous in vitro and in situ studies have reported a shift in optimal muscle fibre length for
force generation (L0) towards longer length at decreasing activation levels (also referred to …
force generation (L0) towards longer length at decreasing activation levels (also referred to …
How octopus arm muscle contractile properties and anatomical organization contribute to arm functional specialization
L Zullo, A Di Clemente, F Maiole - Journal of Experimental …, 2022 - journals.biologists.com
Octopus arms are highly flexible structures capable of complex motions and are used in a
wide repertoire of behaviors. Movements are generated by the coordinated summation of …
wide repertoire of behaviors. Movements are generated by the coordinated summation of …