Antibodies to glutamic acid decarboxylase (GAD) have been associated with several
neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy …

Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in
proliferation and give rise to myelinating oligodendrocytes during early brain development …

Cortical excitability reflects a balance between excitation and inhibition. Glutamate is the
main excitatory and GABA the main inhibitory neurotransmitter in the mammalian cortex …

γ-Aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain.
GABA is also considered to be a multifunctional molecule that has different situational …

Major depression disorder (MDD) is one of the most common psychiatric disorders and one
of the leading causes of disability in worldwide. Both inflammation and GABAergic …

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter that is required for
the control of synaptic excitation/inhibition and neural oscillation. GABA is synthesized by …

Adults express two isoforms of glutamate decarboxylase (GAD), GAD67 and GAD65, which
are encoded by different independently regulated genes, a situation that differs from that of …

Astrocytes play a critical role in regulation of extracellular neurotransmitter levels in the
central nervous system. This function is particularly prominent for the excitatory amino acid …