Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups,
have been widely used in programmable bioengineering. Since nucleic acids are …

The self-assembly of block copolymers is often rationalized by structure and microphase
separation; pathways that diverge from this parameter space may provide new mechanisms …

Precise sequence‐defined polymers (SDPs) with uniform chain‐to‐chain structure including
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …

The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …

Supramolecular interactions such as π-π stacking interaction and charge transfer interaction
have drawn much attention in the design and construction of various supramolecular …

Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein
site-specific intramolecular interactions determine overall structure. Proteins then …

Conspectus Structural DNA nanotechnology offers a unique self-assembly toolbox to
construct soft materials of arbitrary complexity, through bottom-up approaches including …

The morphology of supramolecular materials is usually dictated by directional intermolecular
interactions. However, the impact of the precise monomer sequence–their order along the …

Antisense oligonucleotides (ASOs) can predictably alter RNA processing and control protein
expression; however, challenges in the delivery of these therapeutics to specific tissues …