Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

Regulation of protein synthesis is crucial for cells to maintain viability and to prevent
unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in …

SUMO plays a multiple role in maintenance of cellular homeostasis, both under normal
conditions and under cell stress. Considerable effort has been devoted to unraveling the …

Regulation by the small modifier SUMO is heavily dependent on spatial control of enzymes
that mediate the attachment and removal of SUMO on substrate proteins. Here, we show that …

Covalent modification of the proteome by SUMO is critical for genetic stability and cell
growth. Equally crucial to these processes is the removal of SUMO from its targets by the …

Covalent attachment of the small ubiquitin-like modifier (SUMO) to key targets in the
proteome critically regulates the evolutionarily conserved processes of cell cycle control …

Small ubiquitin-related modifier (SUMO) proteins are efficiently used to target the soluble
expression of various difficult-to-express proteins in E. coli. However, its utilization in large …

Regulation of protein synthesis is of fundamental importance to cells. It has a critical role in
the control of gene expression, and consequently cell growth and proliferation. The …

Candida albicans is a commensal harmless organism which asymptomatically colonises the
human population. However, this organism can become a life-threatening pathogen causing …

Autism spectrum disorders (ASDs) are clinically characterized by decreased communication
abilities, impaired social interaction, and the occurrence of repetitive behaviors, with high …