DNA methylation-based age clocks: From age prediction to age reversion
Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …
progressive decline in physiological functionality and enhanced disease vulnerability …
Recombinant adeno-associated viral vectors (rAAV)-vector elements in ocular gene therapy clinical trials and transgene expression and bioactivity assays
TM Buck, J Wijnholds - International journal of molecular sciences, 2020 - mdpi.com
Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual
function. The development of recombinant adeno-associated viral vectors (rAAV) gene …
function. The development of recombinant adeno-associated viral vectors (rAAV) gene …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
Multiplexed genome regulation in vivo with hyper-efficient Cas12a
Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and
cell engineering. CRISPR–Cas12a systems enable versatile multiple-genomic-loci targeting …
cell engineering. CRISPR–Cas12a systems enable versatile multiple-genomic-loci targeting …
[HTML][HTML] ARDD 2020: from aging mechanisms to interventions
GV Mkrtchyan, K Abdelmohsen, P Andreux… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …
investors. New technologies such as artificial intelligence and advanced screening …
[PDF][PDF] Differentiation reveals latent features of aging and an energy barrier in murine myogenesis
Skeletal muscle experiences a decline in lean mass and regenerative potential with age, in
part due to intrinsic changes in progenitor cells. However, it remains unclear how age …
part due to intrinsic changes in progenitor cells. However, it remains unclear how age …
[HTML][HTML] Epigenetic Reprogramming as a Key to Reverse Ageing and Increase Longevity
B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
DNA break-induced epigenetic drift as a cause of mammalian aging
There are numerous hallmarks of aging in mammals, but no unifying cause has been
identified. In budding yeast, aging is associated with a loss of epigenetic information that …
identified. In budding yeast, aging is associated with a loss of epigenetic information that …
Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways
S Jayarathne, L Ramalingam, H Edwards… - Nutrients, 2020 - mdpi.com
Aging and healthspan are determined by both environmental and genetic factors. The
insulin/insulin-like growth factor-1 (IGF-1) pathway is a key mediator of aging in …
insulin/insulin-like growth factor-1 (IGF-1) pathway is a key mediator of aging in …
Key molecular mechanisms of aging, biomarkers, and potential interventions
The mechanisms of aging are described at the molecular, cell, tissue, and systemic levels.
Primary age-dependent molecular lesions activate the cell stress response to compensate …
Primary age-dependent molecular lesions activate the cell stress response to compensate …