Musculoskeletal research in human space flight–unmet needs for the success of crewed deep space exploration

AM Liphardt, R Fernandez-Gonzalo, K Albracht… - npj …, 2023 - nature.com
Abstract Based on the European Space Agency (ESA) Science in Space Environment
(SciSpacE) community White Paper “Human Physiology–Musculoskeletal system”, this …

The impact of bed rest on human skeletal muscle metabolism

M Eggelbusch, BT Charlton, A Bosutti, B Ganse… - Cell Reports …, 2024 - cell.com
Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal
and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we …

The role of mitochondria in mediation of skeletal muscle repair

SE Alway, HG Paez, CR Pitzer - Muscles, 2023 - mdpi.com
Musculoskeletal health is directly linked to independence and longevity, but disease and
aging impairs muscle mass and health. Complete repair after a pathological or physiological …

Human gut microbiome and metabolite dynamics under simulated microgravity

A Ramos-Nascimento, L Grenga, SB Haange… - Gut …, 2023 - Taylor & Francis
ABSTRACT The Artificial Gravity Bed Rest–European Space Agency (AGBRESA) study was
the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated …

[HTML][HTML] Iron metabolism regulation in females and males exposed to simulated microgravity: results from the randomized trial Artificial Gravity Bed Rest—European …

M Horeau, M Ropert, E Mulder, J Tank… - The American Journal of …, 2022 - Elsevier
Background Iron metabolism imbalance could contribute to physical deconditioning
experienced by astronauts due to its essential role in energy metabolism, cellular …

Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: a scoping review of lateral hip musculature

Z Perraton, P Lawrenson, AB Mosler, JM Elliott… - BMC musculoskeletal …, 2022 - Springer
Background Measures of hip muscle morphology and composition (eg, muscle size and fatty
infiltration) are possible with magnetic resonance imaging (MRI). Standardised protocols or …

New insights into the impact of bed rest on lumbopelvic muscles: A computer-vision model approach to measure fat fraction changes

EO Wesselink, J Hides, JM Elliott… - Journal of Applied …, 2024 - journals.physiology.org
Space agencies plan crewed missions to the Moon and Mars. However, microgravity-
induced lumbopelvic deconditioning, characterized by an increased fat fraction (FF) due to …

[HTML][HTML] MuscleMap: An Open-Source, Community-Supported Consortium for Whole-Body Quantitative MRI of Muscle

MJ McKay, KA Weber, EO Wesselink, ZA Smith… - Journal of …, 2024 - mdpi.com
Disorders affecting the neurological and musculoskeletal systems represent international
health priorities. A significant impediment to progress in trials of new therapies is the …

Research Trends on Astronaut Physical Training as Countermeasures: A Bibliometric Analysis from Past 30 Years

Y Wang, H Wang, Z Yang, Y Chen, DWC Wong… - … Science and Technology, 2024 - Springer
Astronauts are exposed to microgravity-induced health problems in spaceflight missions.
Countermeasures and physical exercises have received increasing attention and its current …

Mid-life cyclists preserve muscle mass and composition: a 3D MRI study

MA Belzunce, J Henckel, AD Laura, LM Horga… - BMC Musculoskeletal …, 2023 - Springer
Physical activity and a healthy lifestyle are crucial factors for delaying and reducing the
effects of sarcopenia. Cycling has gained popularity in the last decades among midlife men …