Diabetes mellitus (DM) is a chronic systemic disease that has increases in prevalence over
time. DM can affect all ocular structures, with cataract being the most common ocular …

Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the
blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to …

Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …

Cataracts remain the first or second leading cause of blindness in all world regions. In the
diabetic population, cataracts not only have a 3–5 times higher incidence than in the healthy …

Cataract is the leading reason of blindness worldwide and is defined by the presence of any
lens opacities or loss of transparency. The most common symptoms of cataract are impaired …

Cataracts are a serious complication of diabetes. In long-term hyperglycemia, intracellular
Ca2+ concentration ([Ca2+] i) and reactive oxygen species (ROS) are increased. The …

Aims Chronic hyperglycemia triggers overproduction of AKR1B1 (aldo-keto reductase family
1 member B) and receptor for advanced glycation end product (RAGE), which causes …

Cataract is a rare manifestation of ocular complication at an early phase of T1DM in the
pediatric population. The pathophysiological mechanism of early diabetic cataract has not …

Abstract Aldose reductase (AR, ALR2; EC 1.1. 1.21), an enzyme that converts glucose to
fructose on the polyol pathway, is an important member of the Aldo‐keto reductase …

Abstract Emblica officinalis Gaetrn (ie, Phyllanthus emblica/Indian gooseberry/Amla)(EO)
has been used extensively as a nutraceutical in several diseases since it is known to boost …