Anti-diabetic effect of telmisartan through its partial PPARγ-agonistic activity

MA Ayza, KA Zewdie, BA Tesfaye… - Diabetes, Metabolic …, 2020 - Taylor & Francis
Telmisartan is an angiotensin II receptor antagonist, which selectively inhibits the
angiotensin II type 1 receptor. Thus, it is widely used for hypertension management …

Telmisartan: just an antihypertensive agent? A literature review

M Destro, F Cagnoni, GP Dognini… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: The modulation of the renin angiotensin aldosterone system (RAAS) is an
important pathway in managing high blood pressure, and its overexpression plays a key role …

Hot-melt extruded amorphous solid dispersion for solubility, stability, and bioavailability enhancement of telmisartan

BR Giri, J Kwon, AQ Vo, AM Bhagurkar, S Bandari… - Pharmaceuticals, 2021 - mdpi.com
Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical
Classification System (BCS) because of its poor aqueous solubility. In this study, we …

Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression

JC Zhong, J Ye, H Jin, X Yu, H Yu, D Zhu, P Gao… - Regulatory peptides, 2011 - Elsevier
Profilin-1 has recently been linked to vascular hypertrophy and remodeling. Here, we
assessed the hypothesis that angiotensin (Ang) II type I receptor antagonist telmisartan …

A 3D in-vitro biomimicking Caco-2 intestinal permeability model-based assessment of physically modified telmisartan towards an alkalizer-free formulation …

SK Sah, K Alam, M Kumari, R Malootty, S Nath… - European Journal of …, 2024 - Elsevier
Efficient telmisartan delivery for hypertension management requires the incorporation of
meglumine and/or sodium hydroxide as an alkalizer in the formulation. Long-term use of …

Telmisartan use and risk of dementia in type 2 diabetes patients with hypertension: A population-based cohort study

CH Liu, PS Sung, YR Li, WK Huang, TW Lee… - PLoS …, 2021 - journals.plos.org
Background Angiotensin receptor blockers (ARBs) may have protective effects against
dementia occurrence in patients with hypertension (HTN). However, whether telmisartan, an …

Quality by Design (QbD) approach to optimize the formulation of a bilayer combination tablet (Telmiduo®) manufactured via high shear wet granulation

AR Lee, SY Kwon, DH Choi, ES Park - International journal of …, 2017 - Elsevier
A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated
based on a Quality by Design (QbD) approach. The control and response factors were …

[HTML][HTML] Effects of telmisartan on metabolic syndrome components: a comprehensive review

M Imenshahidi, A Roohbakhsh… - Biomedicine & …, 2024 - Elsevier
Telmisartan is an antagonist of the angiotensin II receptor used in the management of
hypertension (alone or in combination with other antihypertensive agents. It belongs to the …

Brain penetration of telmisartan, a unique centrally acting angiotensin II type 1 receptor blocker, studied by PET in conscious rhesus macaques

A Noda, H Fushiki, Y Murakami, H Sasaki… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: Telmisartan is a widely used, long-acting antihypertensive agent. Known
to be a selective angiotensin II type 1 (AT1) receptor (AT1R) blocker (ARB), telmisartan acts …

Atrial fibrillation in heart failure patients: An update on renin–angiotensin–aldosterone system pathway blockade as a therapeutic and prevention target

I Koniari, E Artopoulou, V Mplani, F Mulita… - Cardiology …, 2023 - journals.viamedica.pl
Heart failure (HF) and atrial fibrillation (AF) are two cardiovascular (CV) entities that affect
millions of individuals worldwide and their prevalence is translated into a significant impact …