Small and large animal models in cardiac contraction research: advantages and disadvantages

N Milani-Nejad, PML Janssen - Pharmacology & therapeutics, 2014 - Elsevier
The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

[HTML][HTML] (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?

D Mozaffarian, JHY Wu - The Journal of nutrition, 2012 - Elsevier
Considerable research supports cardiovascular benefits of consuming omega-3 PUFA, also
known as (n-3) PUFA, from fish or fish oil. Whether individual long-chain (n-3) PUFA have …

Shortened Ca2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death

AE Belevych, D Terentyev, R Terentyeva… - Circulation …, 2012 - Am Heart Assoc
Rationale: Diastolic spontaneous Ca2+ waves (DCWs) are recognized as important
contributors to triggered arrhythmias. DCWs are thought to arise when [Ca2+] in …

Omega-3 fatty acids in cardiovascular disease–an uphill battle

C von Schacky - Prostaglandins, Leukotrienes and Essential Fatty Acids, 2015 - Elsevier
In cardiology, results of recent large intervention trials with eicosapentaenoic acid (EPA)
plus docosahexaenoic acid (DHA) supplements were neutral. In contrast, in epidemiologic …

The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: a critical reassessment

GE Billman - Pharmacology & therapeutics, 2013 - Elsevier
Although epidemiological studies provide strong evidence for an inverse relationship
between omega-3 polyunsaturated fatty acids (n− 3 PUFAs) and cardiac mortality …

Cardiac physiology and clinical efficacy of dietary fish oil clarified through cellular mechanisms of omega-3 polyunsaturated fatty acids

PL McLennan - European journal of applied physiology, 2014 - Springer
Reduced cardiac mortality and morbidity have long been observed in association with
omega-3 long chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic acid (EPA) …

Electrophysiological mechanisms of the anti-arrhythmic effects of omega-3 fatty acids

ES Richardson, PA Iaizzo, YF Xiao - Journal of cardiovascular …, 2011 - Springer
Heart rhythm disorders, or arrhythmias, are a leading cause of morbidity and mortality
worldwide. Omega-3 polyunsaturated fatty acids (ω3PUFAs), commonly found in fish oils …

Nitric oxide synthases and atrial fibrillation

IM Bonilla, A Sridhar, S Györke, AJ Cardounel… - Frontiers in …, 2012 - frontiersin.org
Oxidative stress has been implicated in the pathogenesis of atrial fibrillation. There are
multiple systems in the myocardium which contribute to redox homeostasis, and loss of …

Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise

GE Billman, WS Harris - American Journal of Physiology …, 2011 - journals.physiology.org
The consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) has been reported to
decrease resting heart rate (HR) and increase heart rate variability (HRV). However, the …

Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation

A Ramadeen, KA Connelly, H Leong-Poi… - Circulation …, 2012 - Am Heart Assoc
Background—The potential health benefits of ω-3 polyunsaturated fatty acids (PUFAs)
usually are studied using a combination of docosahexaenoic acid (DHA) and …