Innovative electrode and chip designs for transendothelial electrical resistance measurements in organs-on-chips
MA Holzreuter, LI Segerink - Lab on a Chip, 2024 - pubs.rsc.org
Many different epithelial and endothelial barriers in the human body ensure the proper
functioning of our organs by controlling which substances can pass from one side to …
functioning of our organs by controlling which substances can pass from one side to …
Integrated biosensors for monitoring microphysiological systems
Microphysiological systems (MPSs), also known as organ-on-a-chip models, aim to
recapitulate the functional components of human tissues or organs in vitro. Over the last …
recapitulate the functional components of human tissues or organs in vitro. Over the last …
A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring
Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-
resembling models than animal models for disease study and drug discovery. Particularly …
resembling models than animal models for disease study and drug discovery. Particularly …
Glutamate oxidase sheets-Prussian blue grafted amperometric biosensor for the real time monitoring of glutamate release from primary cortical neurons
T Rajarathinam, D Thirumalai, S Jayaraman… - International Journal of …, 2024 - Elsevier
Glutamate (GLU) is a primary excitatory neurotransmitter, and its dysregulation is associated
with several neurodegenerative disorders. A major challenge in GLU estimation is the …
with several neurodegenerative disorders. A major challenge in GLU estimation is the …
Recent advances in sensor-integrated brain-on-a-chip devices for real-time brain monitoring
Brain science has remained in the global spotlight as an important field of scientific and
technological discovery. Numerous in vitro and in vivo animal studies have been performed …
technological discovery. Numerous in vitro and in vivo animal studies have been performed …
Organ-on-a-chip platforms integrated with biosensors for precise monitoring of the cells and cellular microenvironment
W Yang, T Li, S Liao, J Zhou, L Huang - TrAC Trends in Analytical …, 2024 - Elsevier
Abstract Organs-on-chips (OoCs) are in vitro models that simulate the anatomical and
physiological structure of human organs at the micro-scale level. With the advantages of …
physiological structure of human organs at the micro-scale level. With the advantages of …
μF-hBBB chip together with tetrahedral DNA frameworks for visualization of LPS-mediated inflammation
Y Xu, S Li, C Wang, X Xie, X Mi - Analytical Chemistry, 2023 - ACS Publications
The blood–brain barrier (BBB) is essential for maintaining central nervous system (CNS)
stability, and neuroinflammation may cause the dysfunction of the BBB. MicroRNA-146a …
stability, and neuroinflammation may cause the dysfunction of the BBB. MicroRNA-146a …
Biosensor integrated brain-on-a-chip platforms: progress and prospects in clinical translation
Because of the brain's complexity, developing effective treatments for neurological disorders
is a formidable challenge. Research efforts to this end are advancing as in vitro systems …
is a formidable challenge. Research efforts to this end are advancing as in vitro systems …
Lab-on-a-chip models of the blood–brain barrier: Evolution, problems, perspectives
A great progress has been made in the development and use of lab-on-a-chip devices to
model and study the blood–brain barrier (BBB) in the last decade. We present the main …
model and study the blood–brain barrier (BBB) in the last decade. We present the main …
[HTML][HTML] Sensorization of microfluidic brain-on-a-chip devices: Towards a new generation of integrated drug screening systems
Abstract Brain-on-a-chip (BoC) devices show typical characteristics of brain complexity,
including the presence of different cell types, separation in different compartments, tissue …
including the presence of different cell types, separation in different compartments, tissue …